Table 1.
Summary of Included Studies.
| Lead author | Journal | Year of publication | Level of evidence | Number of subjects | Intervention | Outcome measures reported |
|---|---|---|---|---|---|---|
| Basad30 | KSSTA | 2010 | Level 1 | 33 | Matrix-induced ACI | Tegner, Lysholm |
| 15 | Microfracture | |||||
| Cerynik31 | KSSTA | 2009 | Level 3 | 24 | Microfractured NBA players | RTP |
| 24 | Control NBA players | |||||
| Cole32 | AJSM | 2011 | Level 2 | 20 | CAIS | IKDC, KOOS |
| 9 | Microfracture | |||||
| Ebert33 | AJSM | 2012 | Level 1 | 31 | ACI: Accelerated rehabilitation | SF-36, KOOS, RTP |
| 32 | ACI: Traditional rehabilitation | |||||
| Gobbi34 | KSSTA | 2005 | Level 2 | 53 | Microfracture | Tegner, Lysholm, RTP |
| Gooding35 | The Knee | 2006 | Level 1 | 35 | OAT | Cincinnati |
| 33 | Microfracture | |||||
| Gudas12 | KSSTA | 2006 | Level 1 | 29 | OAT | RTP |
| 28 | Microfracture | |||||
| Horas36 | JBJS | 2003 | Level 2 | 20 | ACI | Tegner, Lysholm |
| 20 | OAT | |||||
| Knutsen24 | JBJS | 2007 | Level 1 | 40 | ACI | SF-36, Tegner, Lysholm |
| 40 | Microfracture | |||||
| Kon13 | AJSM | 2011 | Level 2 | 21 | ACI | IKDC, Tegner, RTP |
| 20 | Microfracture | |||||
| Kreuz37 | AJSM | 2007 | Level 2 | 49 | ACI without athletic involvement | Cincinnati, RTP |
| 69 | ACI with athletic involvement | |||||
| Krych38 | JBJS | 2012 | Level 3 | 48 | OAT | SF-36, Marx, IKDC, KOOS |
| 48 | Microfracture | |||||
| Lim39 | CORR | 2012 | Level 2 | 18 | ACI | Tegner, Lysholm |
| 22 | OAT | |||||
| 30 | Microfracture | |||||
| Marder40 | Arthroscopy | 2005 | Level 3 | 23 | Microfracture and TDWB | Tegner, Lysholm |
| 20 | Microfracture and WBAT | |||||
| Micheli41 | CJSM | 2001 | Level 2 | 50 | ACI | Cincinnati |
| Niemeyer42 | AJSM | 2010 | Level 2 | 37 | ACI in patients >40 years old | IKDC, Tegner, Cincinnati, ICRS, Lysholm |
| 37 | ACI in patients <40 years old | |||||
| Panagopoulos43 | Orthopedics | 2012 | Level 2 | 11 | Periosteal patch ACI | IKDC, Tegner, Lysholm |
| 8 | Matrix-assisted ACI | |||||
| Pestka44 | AJSM | 2012 | Level 3 | 28 | ACI after microfracture | IKDC, KOOS, RTP |
| 28 | ACI as primary treatment | |||||
| Vanlauwe45 | AJSM | 2011 | Level 1 | 57 | ACI | KOOS |
| 61 | Microfracture | |||||
| (continued) | ||||||
| Zaslav46 | AJSM | 2009 | Level 2 | 126 | ACI with prior failed surgical intervention | KOOS, Cincinnati |
| 60 | ACI with prior failed debridement | |||||
| 42 | ACI with prior failed microfracture | |||||
| Total | 1,375 | |||||
Note: KSSTA = Knee Surgery, Sports, Traumatology, and Arthroscopy; AJSM = American Journal of Sports Medicine; CJSM = Clinical Journal of Sports Medicine; JBJS = Journal of Bone and Joint Surgery; CORR = Clinical Orthopaedics and Related Research; ACI = autologous chondrocyte implantation; NBA = National Basketball Association; CAIS = cartilage autograft implantation system; OAT = osteochondral autograft transplantation; TDWB = touch-down weightbearing; WBAT = weightbearing as tolerated; KOOS = Knee Injury and Osteoarthritis Outcome Score; IKDC = International Knee Documentation Committee Score; RTP = return to play data; SF-36 = Short Form-36 Quality of Life Outcome Score.