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. 2012 Apr;3(2):128–140. doi: 10.1177/1947603511429698

Figure 4.

Figure 4.

Effects of IL-1β on bovine chondrocytes cultured in PEGDA hydrogels for up to 3 weeks with growth media (CCM). *P < 0.05, **P < 0.01, and ***P < 0.001. (A) Sustained treatment (light gray) resulted in no significant increase of GAG content over time, while only 3 days of cytokine treatment (dark gray) resulted in comparable GAG content versus control after 3 weeks (n = 3). (B) Sustained exposure to IL-1β decreased anabolic gene expression and increased catabolic gene expression related to cartilage metabolism (n = 3). (C) Exposure to IL-1β resulted in less Safranin-O staining and smaller morphology than the control with no IL-1β. White bars on pictures indicate a scale of 100 µm.