Table 5.

Adverse Events (AEs) Reported during the 12-Month Time Course of the Investigator-Initiated Trial with the Spheroids in co.don chondrosphere

AE (reported term)	MedDRA preferred term (PT) version 13.1	MedDRA system organ class (SOC) version 13.1	No. of patients with an AEa	Intensity of the AE	Seriousness of the AE	Relation to transplantation surgery	Causally related to co.don chondrosphere
Swelling	Swelling	General disorders and administration site conditions	1	Mild	Nonserious	Yes	No
Knee joint effusion	Joint effusion	Musculoskeletal and connective tissue disorders	1	Mild	Nonserious	Yes	Probable
Blocking	Joint lock	Musculoskeletal and connective tissue disorders	2	Moderate	Nonserious	Yes	Possible
Thrombosis (superficial)	Thrombophlebitis (superficial)	Vascular disorders	1	Moderate	Nonserious	Yes	No
Infection	Infection	Infections and infestations	1	Severe	Nonserious	Yes	No
Deep vein thrombosis	Deep vein thrombosis	Vascular disorders	1	Severe	Serious	Yes	No
Pulmonary embolism	Pulmonary embolism	Respiratory, thoracic, and mediastinal disorders	1	Severe	Serious	Yes	No

^aA patient may have experienced more than one AE.