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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2014 Nov 12;14(1):120–128. doi: 10.1158/1535-7163.MCT-14-0366

Figure 4. iRGD repels tumor cells.

Figure 4

A, iRGD-coated silver nanoparticles (iRGD-AgNPs) or CRGDC-AgNPs were blotted on glass surfaces, and cells were seeded in the center in close proximity with the AgNPs. Cells were imaged for 48 hours. Representative images at 0, 24, and 48 hours are shown. The dark areas are coated with AgNPs. The dotted lines show the edge of the migrating cell populations. Note that the cells are repelled by iRGD-AgNPs, while they progressively migrate over CRGDC-AgNPs and completely saturate the field in 48 hours. n = 5. B, Cells were seeded on glass surfaces densely coated with the indicated AgNPs and imaged for 48 hours. The speed of cell migration was quantified by measuring %AgNP area covered by the cells. Error bars, mean ± SEM; statistical analyses, ANOVA; *P < 0.05; ***P < 0.001.