Table 1. Antiproliferative effect of LIMKi on PC cell lines.
All cell lines were treated with half-log serial dilutions of LIMKi for 72 hours. EC50 values were measured from dose-response curves from three independent experiments performed in triplicates.
| Cell line | LIMKi EC50, μM | p value, F test (compared to LNCaP) |
|---|---|---|
| LNCaP | 1.33 | - |
| CWR22 | 6.97 | <0.0001 |
| LNCaP-AI | 11.11 | <0.0001 |
| DU145 | 11.46 | <0.0001 |
| PC3 | 12.68 | <0.0001 |