Fig. 4.

AG-014699- and AZD-2281-mediated activation of Akt and ERK might be attributable to downregulation of PHLPP expression in MDA-MB-468 cells, a Dose-dependent effects of AG-014699 and AZD-2281 versus ABT-888 on PHLPP expression after 72 h of treatment, b Effect of LY-294002 (10 µM) on AG-014699- and AZD-2281-mediated phosphorylation of Ser473-Akt and ERKs