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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Shock. 2015 Feb;43(2):133–139. doi: 10.1097/SHK.0000000000000276

Figure 1.

Figure 1

Observed changes in vital signs after endotoxin administration in human volunteers. A dose-dependent relationship is observed with numerically significant differences (p<0.05) from placebo with larger doses endotoxin for (A) Temperature (>0.25 ng/kg) and (B) Heart Rate (>0.5 ng/kg) response. Only at the 1 and 2 ng/kg doses did changes occur in temperature and heart rate which would consistently meet SIRS criteria. For Mean Arterial Pressure (C), no consistent or significant dose-response pattern was discernable after endotoxin.