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Model of inflammasome assembly. NLRP3 or AIM2 (not shown) nucleate ASC-PYD polymerization. (a) The polymeric assembly of ASC and caspase-1 and (b) a cross section of the polymer has been modified from Lu and colleagues [59]. (c) An alternative model, observed in macrophages after Salmonella infection, modified from Man and colleagues [93]. In this model, the sensors are composed of a complex of NLRP3 and NLRC4 (not shown).
