| Active medication compared with placebo | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) |
No of participants (studies) |
Quality of the evidence (GRADE) |
Comments | |
|
|
||||||
| Assumed risk | Corresponding risk | |||||
|
|
||||||
| Control | Active Medication | |||||
|
Completion of treatment
- THC preparations |
Study population
|
RR 1.29
(1.08 to 1.55) |
207 (2 studies) |
⊕⊕⊕○ moderate2 |
||
| 614 per 1000 |
792 per 1000
(663 to 951) |
|||||
|
|
||||||
|
Moderate
|
||||||
| 618 per 1000 |
797 per 1000
(667 to 958) |
|||||
|
| ||||||
|
Completion of treatment
- mixed action antide- pressants |
Study population
|
RR 0.93
(0.71 to 1.21) |
169 (2 studies) |
⊕⊕⊕○ moderate2 |
||
| 573 per 1000 |
533 per 1000
(407 to 694) |
|||||
|
|
||||||
|
Moderate
|
||||||
| 551 per 1000 |
512 per 1000
(391 to 667) |
|||||
|
| ||||||
|
Completion of treatment
- SSRI antidepressants |
Study population
|
RR 0.82
(0.44 to 1.53) |
122 (2 studies) |
⊕○○○ very low1,2,3 |
||
| 790 per 1000 |
648 per 1000
(348 to 1000) |
|||||
|
|
||||||
|
Moderate
|
||||||
| 766 per 1000 |
628 per 1000
(337 to 1000) |
|||||
|
| ||||||
|
Completion of treatment
- anticonvulsant and mood stabiliser |
Study population
|
RR 0.78
(0.42 to 1.46) |
75 (2 studies) |
⊕○○○ very low2,3 |
||
| 405 per 1000 |
316 per 1000
(170 to 592) |
|||||
|
|
||||||
|
Moderate
|
||||||
| 387 per 1000 |
302 per 1000
(163 to 565) |
|||||
|
| ||||||
|
Completion of treatment
- atypical antidepressant (bupropion) |
Study population
|
RR 1.06
(0.67 to 1.67) |
92 (2 studies) |
⊕○○○ very low2,3 |
||
| 429 per 1000 |
454 per 1000
(287 to 716) |
|||||
|
|
||||||
|
Moderate
|
||||||
|
400 per 1000
|
424 per 1000
(268 to 668) |
|||||
The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval; RR: Risk ratio
GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.
Significant heterogeneity between studies
Studies small (<300 participants in total)
One study at risk of attrition bias