Figure 1.
Carbon monoxide-releasing molecule protected against hemorrhagic shock and resuscitation-induced organ injury and inflammation. A, B. HS/R resulted in liver and kidney injury as determined by serum ALT and cystatin C, respectively (*P<0.05 compared to sham, control mice). CORM treatment limited organ injury (#P<0.05 compared to shock, control mice). C-E. HS/R increased serum IL-6, TNF-α, and IL-1α levels (*P<0.05 compared to sham, control mice). Mice treated with CORM protected against HS/R-induced elaboration of cytokines (#P<0.05 compared to shock, control mice).