Table 2.

Whole brain and regional gray and white matter brain volumes across groups. Values for regional brain volumes are fractions of respective tissue type per volume.

Whole Brain Volumes	Control Women, n =24		Obese Women, n=18		t	p
	Mean	SD	Mean	SD
Gray Matter Volume (cm3)	629.65	62.12	627.98	51.13	0.09	0.926
White Matter Matter Volume (cm3)	494.00	44.34	492.01	42.41	0.15	0.884
Cerebral Spinal Fluid Volume (cm3)	226.81	30.63	254.14	28.76	−2.94	0.005
Total Intracranial Volume (cm3)	1350.47	105.28	1374.13	100.49	−0.73	0.467
Anatomical Region	Cluster Size	p FWE-Corr	T/Z at peak	MNI Coordinates
GM Volume Ratio				x	y	z
L Amygdala, BA 38	154	0.001	4.36/4.09	−26	5	−29
R Caudate	59	0.011	4.23/3.79	8	18	−9
R Superior Orbitofrontal Cortex, BA 11	38	0.008	4.39/3.91	9	56	−24
R Medial Orbitofrontal Cortex, Gyrus Rectus	4	0.017	3.98/3.61	17	23	−12
R Medial Orbitofrontal Cortex, Gyrus Rectus, BA 11	12	0.032	3.71/3.40	6	56	−23
R Anterior Cingulum, BA 32	2	0.033	3.91/3.55	6	20	−8
R Hippocampus	80	0.021	3.97/3.60	35	−13	−14
L Hippocampus	232	0.004	4.62/4.08	−36	−9	−18
WM Volume Ratio
L Amygdala	63	0.003	4.26/3.82	−30	−4	−29
R Caudate	192	0.001	5.16/4.45	15	8	21
L Caudate	354	0.001	5.18/4.47	−15	8	19
R Medial Orbitofrontal Cortex	36	0.015	3.92/3.56	8	30	−14
L Medial Orbitofrontal Cortex	98	0.001	4.93/4.29	−12	50	−14
L Middle Orbitofrontal Cortex	3	0.021	3.93/3.57	−15	50	−18
L Superior Orbitofrontal Cortex	185	0.003	4.82/4.22	−14	48	−15
R Insula	135	0.005	4.78/4.19	30	27	12
R Insula, BA 13	22	0.045	3.87/3.52	38	−13	22
L Insula, BA 13	22	0.029	4.04/3.65	−36	−25	22
L Insula	7	0.049	3.81/3.48	−44	−3	−9
R Medial Orbitofrontal Cortex, Gyrus Rectus	29	0.030	3.71/3.40	8	29	−15
L Medial Orbitofrontal Cortex, Gyrus Rectus	97	0.001	4.93/4.30	−12	48	−15
R Anterior Cingulum	272	<0.001	6.00/4.98	9	29	22
R Anterior Cingulum	1	0.002	4.92/3.57	11	50	10
R Anterior Cingulum	24	0.011	4.35/3.89	11	47	4
R Anterior Cingulum	4	0.043	3.78/3.45	9	48	13
R Anterior Cingulum	53	0.048	3.73/3.42	11	32	−11
L Anterior Cingulum	437	0.002	5.01/4.35	−2	24	21
L Anterior Cingulum	70	0.002	5.03/4.36	−15	48	7
R Hippocampus	139	0.014	4.11/3.71	35	−15	−23
L Hippocampus	65	<0.001	5.46/4.64	−30	−12	−24
R Rolandic Operculum	11	0.042	3.66/3.36	38	−13	21
R Rolandic Operculum	21	0.006	4.46/3.96	44	−28	22
R Rolandic Operculum	11	0.019	3.66/3.36	45	−24	22
L Rolandic Operculum	179	0.019	4.08/3.68	−39	−24	22

Control Women > Obese Women; Whole-brain volumes represented as raw values. Regional brain volume contrasts based on group comparison corrected for total intracranial volume and depression. FWE-corr = family-wise error corrected; L = left; MNI = Montreal Neurological Institute; R = right.