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3-pool model of a water proton pool (pool a), one solute pool with exchanging site (CEST pool b), and the semi-solid MT pool of bound water (pool c). All pools recover magnetization by their longitudinal relaxation rate R1, and loose magnetization by R2, due to RF irradiation with amplitude B1=ω1/γ. The exchange rate kca of the MT pool is typically in the range of several 10 s−1.
