Table 2.

Synthesized derivatives and their effect at α1β2γ2 GABA_A receptor

Compound	R	Yield	% IGABA at 3 μM
8a	H	58	Inactive
8b	o-Me	34	207 ± 33
8c	m-Me	39	Inactive
8d	p-Me	46	84 ± 11
8e	o-OMe	54	Inactive
8f	m-OMe	48	136 ± 32
8g	p-OMe	34	443 ± 60
8h	Lactone	31	Inactive
8i	m-COOMe	34	406 ± 70
8j	p-COOMe	36	Inactive
8k	o-NO2	42	Inactive
8l	m-NO2	86	Inactive
8m	p-NO2	60	Inactive
2	—	—	162 ± 31
1	—	—	338 ± 93