Table 1.
Selected Examples of Cancer-related LncRNAs
| lncRNA Category | lncRNA Names | Functions | References |
|---|---|---|---|
| Oncogenes | PCAT1 | Represses DNA repair | [25] |
| PRNCR1 and PCGEM1 | Govern AR-mediated gene transcription | [26] | |
| CBR3-AS1 | Changes AR activity | [27] | |
| MALAT1 and MASCRNA | Mediate alternative splicing | [28] | |
| SCHLAP1 | Regulates transcription complex | [29] | |
| PVT1 | Hosts several miRNA genes | [30] | |
| HOTAIR | Binds PRC2 and LSD1 | [31] | |
| H19 | Imprints Igf2 locus | [32] | |
| Tumor Suppressors | MEG3 | Mediates p53 signaling | [33] |
| GAS5 | Prevents GR-mediated gene expression | [34] | |
| PTENP1 | Competes PTEN-regulating miRNAs | [35] | |
| CCND1 | Binds to TLS protein | [36] | |
| lncRNA-p21 | Binds to hnRNP-K and induces cellular apoptosis | [37] |