Table 1.
Pharmacokinetic data of Raltegravir after administration of different dosages of raltegravir by chewing or swallowing the drug in a patient with AIDS and MAI infection
| Parameter | Raltegravir concentration (ng/ml) | |||
|---|---|---|---|---|
| 400 mg swallowed | 400 mg chewed | 800 mg swallowed | 800 mg chewed | |
| C0h | 66 | <45 | 439 | 47 |
| C1 h | 884 | 865 | 511 | 676 |
| C2 h | 904 | 930 | 781 | 660 |
| C4 h | 699 | 207 | 1055 | 1147 |
| C8 h | 71 | 173 | 1032 | 723 |
| C12 h | 62 | 94 | 885 | 372 |
| AUC0–4 | 2972 | 2489 | 2957 | 2837 |
| AUC12 | 4778 | 3783 | 10965 | 8767 |
| Difference AUC 12 (ng/ml); median; min; max | −3,5;-102;492 | 215;-165;513 | ||
| (p-value) | (p-value 0,84) | (p-value 0,22) | ||