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. 2014 Dec 24;14:700. doi: 10.1186/s12879-014-0700-3

Table 2.

Listing of birth defects detected by timing of antiretroviral therapy exposure

Birth defects Earliest antiretroviral exposure
First trimester (n = 329) Second/third trimester (n = 488) None (n = 80)
Central Nervous System
 Microcephaly 0 1 0
Face/neck/eyes/ears
 Morrie syndrome 0 1 0
 Microphthalmia 1 0 0
 Coloboma 0 0 1
 Syndromic facies 0 0
Cardiovascular and circulatory defects
 Atrial septal defect 5 4 0
 Ventricular septal defect 2 2 0
 Transposition of the great arteries 1 0 0
 Pulmonary valve stenosis 0 2* 0
 Hypoplastic left heart syndrome 1† 0 0
Respiratory 0 0 0
Digestive system
 Hepatic venous malformation 0 1 0
 Hepatic lymphangioma 0 1 0
 Alagille syndrome 0 2# 0
 Oesophageal atresia 1‡ 0 0
 Diaphragmatic hernia 1 0 0
Genital organs
 Cryptorchidism 3 1 2
 Double urethra 0 1 0
 Vaginal polyp 1 0 0
Urinary system
 Hydronephrosis 2 5 0
 Hypospadias 0 3 0
 Renal duplication and ureterocele 0 1 0
Musculoskeletal
 Premature synostosis 1 1 0
 Clubfeet 0 1 0
 Phocomelia 0 1 0
 Congenital hip dislocation 3 0 0
 Congenital knee dislocation 0 1 0
Limbs
 Syndatyly 0 1 0
 Polydactyly 0 1 0
Miscellaneous defects
 Pierre Robin syndrome 0 1 0
 Fetal alcohol syndrome 0 0 2
 Trisomy 21 0 1 1
Total infants with defects 23 33 6

*Includes one case with atrial septal defect.

#Both patients also had tracheal stenosis.

†This patient also had hydronephrosis.

‡This patient also had vertebral bodies abnormalities and left superior caval vein.

§This patient also had blepharophimosis and developmental delay.