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. Author manuscript; available in PMC: 2015 Jan 17.
Published in final edited form as: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Oct;36(10):927–938. doi: 10.3969/j.issn.1672-7347.2011.10.002

Fig. 1.

Fig. 1

A:Schematic representation of the topological structure of MRP1/ABCC1 protein predicted using TOPO2 program with modification (http://www.sacs.ucsf.edu/TOPO-run/wtopo.pl). The consensus sequences of Walker A and B are highlighted in orange and green, respectively. The ABC-signature motif is highlighted in red. TM, transmembrane; MSD, membrane spanning domain; NBD, nucleotide-binding domain. B: Distribution of clinically relevant MRP1/ABCC1 exon polymorphisms.