Tab. 1.
Clinically relevant substrates of MRP1/ABCC1 *
| Type of substrates | Examples |
|---|---|
| Drugs | Anticancer drugs |
| Vinca alkaloids: vinblastine and vincristine | |
| Epipodophyllotoxins: etoposide (VP-16) and teniposide | |
| Camptothecins: topotecan, irinotecan and SN-38 | |
| Methotrexate and mitoxantrone | |
| Other drugs | |
| Anti HIV drugs; ritonavir and saquinavir | |
| Antibiotics: difloxacin and grepafloxicin | |
| Tyrosine kinase inhibitors: imatinib mesylate and gefitinib | |
| Heavy metal anions | Arsenite |
| Arsenate | |
| Trivalent and pentavalent antimonials | |
| Glutathione conjugates(-GS) | Dinitrophenyl-GS |
| Etacrynic acid-GS | |
| Doxorubicin-GS | |
| Cyclophosphamide-GS | |
| Melphalan-GS | |
| Aflatoxin B1-epoxide-GS | |
| Hydroxynonenal-GS | |
| Prostaglandin A2-GS | |
| Glutathione (GSH, GSSG) | |
| Glucuronide conjugates (-G) | Bilirubin-G |
| Estradiol 17βD-G | |
| Hyodeoxycholate-G | |
| Etoposide (VP-16)-G | |
| NS-38-G | |
| Sulfate conjugates (-S) | Estrone-3-S |
| Taurocholate-3-S | |
| Dehydroepiandrosterone-3-S | |
| Sulfatolithocholyl taurine | |
| Folates | Folic acid |
| L-leucovorin | |
| Toxicants | Aflatoxin B1 |
| Methoxychlor | |
| Fenitrothion | |
| Others | Leukotrienes C4, D4 and E4 |
| Curcuminoids | |
| Calcein |