Tab. 2.

Association of MRP1/ABCC1 polymorphisms with therapeutic response

Polymorphisms	rs number	Amino acid exchange	Location	Drugs	Disease/Observation	References
G2012T	rs45511401	Gly671Val	Exon 16	Atorvastatin	Hypercholesterolemia/No correlation	[42]
				Telatinib	Solid tumor/No correlation	[44]
				Induction Therapy	Leukemia/No correlation	[43]
G4002A	rs2239330	No change	Exon 28	Gemcitabine, cisplatin, taxane, methotrexate	Pancreatic cancer/No correlation	[45-47]
				Citalopram	Major depressive disorder/Strong correlation	[48]
G2168A	rs4148356	Arg723Gln	Exon 17	Platinum	Ovarian cancer/Correlation	[50]
				Taxane	Ovarian cancer/Correlation	[50]
A4009G	rs28364006	Alal337Thr	Exon 28	Methotrexate	Psoriasis/Correlation	[49]
IVS23 G-1960A	rs2238476	No change	Intron 23	Methotrexate	Psoriasis/Correlation	[49]
IVS9 T-176C	rs35592	No change	Intron 9	Methotrexate	Psoriasis/Correlation	[49]
T2684C		No change	Exon 21		Leukemic/No correlation	[43]
C2007T	rs2301666	No change	Exon 16		Leukemic/No correlation	[43]
G2012T	rs45511401	Gly671Val	Exon 16		Leukemic/No correlation	[43]
C2665T		No change	Exon 21		Leukemic/No correlation	[43]
IVS1 C-14840T	rsll9774	No change	Intron 1	Montelukast	Asthma/Correlation	[28]
				Zileuton	Asthma/Correlation	[29]
GCC repeat		No change	5′UTR	Azithromycin	Cystic fibrosis/No correlation	[72]
IVS18 C -30G	rs2074087	No change	Intron 18	Taxanes	Ovarian cancer/No correlation	[47]