Fig 1.

Quantitative analysis of pluripotency and neural stem cell (NSC) marker expression following forced expression of exogenous Oct4 in the tissue collected from the rims of injected brain ventricles. A. Total (Endogenous + exogenous) Oct4 expression, B. Endogenous Oct4 expression, C. Nanog expression, D. Klf4 expression, E. c-Myc expression, F. Sox2 expression, G. Pax6 expression and H. Sox1 expression in different groups. Results were normalized by GAPDH as a housekeeping gene. Vehicle; 7 days PBS i.c.v injection, O7; Oct4 expressing lentivirus i.c.v injection followed by doxycycline i.c.v injections for another 7 consecutive days and O14; Oct4 expressing lentivirus i.c.v injection followed by doxycycline i.c.v injections for another 14 consecutive days. Each group contains 5-7 animals. *; P<0.05.