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. Author manuscript; available in PMC: 2016 Feb 15.
Published in final edited form as: Biol Psychiatry. 2014 Aug 27;77(4):404–415. doi: 10.1016/j.biopsych.2014.07.033

Fig. 4. Chocolate flavoured pellets self-administration.

Fig. 4

(A) Acquisition and maintenance. Mean number of active and inactive nose-pokes during 10 days of FR1, 5 days of FR5 and 10 days of extinction in 1 h daily sessions. (B) Motivation. Mean breaking point achieved in a session of progressive ratio that was conducted once and lasted 5 h. (C) Cue-induced reinstatement. Mean number of active nose-pokes during the different experimental phases: mean of the 3 days of the acquisition criteria of chocolate self-administration during FR1 and FR5, mean of the 3 days of the acquisition of the extinction criteria and cue-induced reinstatement. Ctrl (n = 23) and Dlx-DOR mice (n = 16). Data are expressed as mean ± SEM. One star, P<0.05; two stars, P<0.01 comparison between genotypes (three-way ANOVA).