Figure 6. IL-4Rα signaling in adipocyte precursors directs growth of beige fat.
(A) Representative sections of scWAT from 5 week-old Il4raf/f and Il4raf/f/PdgfraCre mice were stained with hematoxylin and eosin. 100× magnification (top panels), 400× magnification (bottom panels). (B) UCP1 protein expression in scWAT and BAT of 5 week-old Il4raf/f and Il4raf/f/PdgfraCre mice housed at 22°C (n=3 per genotype). (C–F) Assessment of metabolic rate, food intake, and activity in 5-week-old Il4raf/f and Il4raf/f/PdgfraCre mice housed at 22°C (n=8 per genotype); (C) oxygen consumption (VO2), (D) RER, (E) food intake, and (F) total activity. Data are represented as mean ± SEM.