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. Author manuscript; available in PMC: 2016 Feb 15.
Published in final edited form as: Biol Psychiatry. 2014 Aug 15;77(4):385–393. doi: 10.1016/j.biopsych.2014.08.006

Figure 3.

Figure 3

Signal amplitude results from models of only categorical, dimensional, or both categorical and dimensional models of anxiety and depression for all participants, plotting estimated marginal means and their standard errors. For the categorical model, (A) a specific effect of GAD on limbic/paralimbic signal amplitude was found. For the dimensional only model, there was a significant positive relationship between the broad symptom of general distress and limbic/paralimbic signal amplitude (B) that remained significant in the combined categorical and dimensional model (C) after accounting for other symptoms and diagnostic categories. In the combined model, a main effect of MDD was driven by overall lower signal amplitudes for MDD patients compared to individuals without MDD (D).