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. Author manuscript; available in PMC: 2016 Jan 15.
Published in final edited form as: Cancer Res. 2014 Nov 11;75(2):436–445. doi: 10.1158/0008-5472.CAN-14-1041

Figure 3. The expression of miR-99a, miR-125b, and let-7c is lowest in patients with luminal B breast cancer and predicts outcome in luminal A breast cancer.

Figure 3

A) Patients with breast cancer from TCGA who were profiled for their mRNA and miRNA expression were analyzed for the expression of let-7c, miR-99a, miR-125b in the different PAM50 clinical subsets. All three miRNAs are expressed at the lowest levels in patients with luminal B breast cancer. *, p < 0.01; **, p < 0.001; p < 0.0001. B) The TCGA patients from A were clustered via hierarchical clustering, and the expression of let-7c, miR-99a, miR-125b is shown for each of the patient subsets. The dotted red box demonstrates the subset of luminal A patients with lower expression of the let-7c/miR-99a/miR-125b cluster C) Kaplan-Meier plot demonstrating the overall survival probability for patients with luminal A breast cancer based on the expression of let-7c, miR-99a, and miR-125b.