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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Pediatr Nephrol. 2014 Jul 17;30(6):881–887. doi: 10.1007/s00467-014-2880-x

Table 3.

Summary of studies applying metabolomics in pediatric nephrology

First author (year) Biological sample Clinical setting Method Metabolites
Beger (2008) Urine AKI following cardiac surgery LC-MS Homovanillic-acid sulfate (HVA-SO4)
Atzori (2010) Urine Nephrouropathies NMR Purine, pyridine
Atzori (2011) Urine Young adults born extremely low-birth weight NMR N-Methylhydantoin, glycine, valine, glutamine
Zivkovic (2012) Serum Immunoglobulin A nephropathy LC-MS/MS Total oxylipins, hydroxyoctadecadienoic acids, hydroxyeicosatetraenoic acids, leukotriene B4
Peretz (2011) Urine Children and adults from 11 families affected by classical xanthinuria LC-MS hydantoin propionic acid, N1-methyl-8- oxoguanine, N-(3-acetamidopropyl)pyrrolidin-2-one

LC-MS, liquid chromatography-mass spectrometry; NMR, nuclear magnetic resonance;