Table 3. Median post-treatment urinary cytokines by week of therapy.

	Median (IQR) urinary cytokine concentration (pg/ml)
Cytokine	Week 1	Week 4	Week 6	P-value*
IL-2	0.0 (0-0.5)	25.7 (7.6-73.1)	40.3 (15.5 – 147.2)	0.006
IL-4	0.16 (0-1.7)	0.62 (0.08-6.1)	3.88 (1.87-20.18)	0.18
IL-8	171.7 (54.1-1061)	681.7 (413.3-1724)	3212 (958.2-4787)	0.007
IL-10	2.3 (1.6-3.1)	29.5 (2.3-654.2)	121.7 (9.8-510.4)	0.023
IL-17	3.5 (2.7-8.0)	66.0 (16.4-411.1)	623.9 (41.4-942.6)	0.085
IFN-γ	0.0 (0.0-4.3)	17.0 (0.7-42.8)	107.9 (1.0-239.6)	0.072
TNF-α	2.3 (1.3-44.8)	569.6 (21.6-2445)	2149 (42.1-2449)	0.024

^*P-value by non-parametric test for trend. IFN, interferon. IL, interleukin. TNF, tumor necrosis factor. IQR, interquartile range