. Author manuscript; available in PMC: 2016 Jan 31.

Published in final edited form as: Biol Blood Marrow Transplant. 2014 Nov 20;21(2):259–265. doi: 10.1016/j.bbmt.2014.09.016

Table 4.

Association between TLR1, 4, 6 and 9 genotype and outcome after allogeneic HCT

Variable	Genotype	Patient TLR1 (rs5743611)			Patient TLR4 (rs4986790)
Variable	Genotype	n	HR (95% CI)	p	n	HR (95% CI)	p
OS	AA	666	1.000		696	1.000
	Aa	114	1.017 (0.779–1.328)	0.902	96	1.424 (1.089–1.863)	0.010
	aa	12	1.432 (0.729–2.813	0.297	0	NA	NA
DFS	AA	662	1.000		689	1.000
	Aa	112	0.988 (0.758–1.286)	0.927	96	1.363 (1.047–1.774)	0.0214
	aa	11	1.195 (0.585–2.443)	0.625	0	NA	NA
Relapse	AA	662	1.000		689	1.000
	Aa	112	0.945 (0.584–1.530)	0.819	96	1.034 (0.592–1.805)	0.907
	aa	11	2.054 (0.740–5.704)	0.167	0	NA	NA
TRM	AA	662	1.000		689	1.000
	Aa	112	0.950 (0.692–1.304)	0.751	96	1.515 (1.123.2.042)	0.007
	aa	11	0.860 (0.316–2.335)	0.767	0	NA	NA
aGVHD
Grade II–IV	AA	659	1.000		689	1.000
	Aa	114	1.231 (0.947–0.294)	0.121	96	1.120 (0.839–1.495)	0.442
	aa	12	0.714 (0.294–1.735)	0.457	0	NA	NA
Grade III–IV	AA	638	1.000		668	1.000
	Aa	112	1.553 (1.054–2.290)	0.026	94	1.071 (0.686–1.672)	0.763
	aa	12	0.267 (0.037–1.935)	0.191	0	NA	NA
cGVHD	AA	650	1.000		682	1.000
	Aa	112	1.064 (0.807–1.403)	0.660	92	0.789 (0.561–1.109)	0.172
	aa	12	1.026 (0.451–2.336)	0.951	0	NA	NA