Table 5.
| Variable | Donor TLR4 (rs4986790) | Patient TLR6 (rs5743810) | Patient TLR9 (rs187084) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | HR (95% CI) | p | n | HR (95% CI) | p | n | HR (95% CI) | p | ||
| OS | 703 | 1.000 | 247 | 1.000 | 278 | 1.000 | ||||
| 102 | 1.204 (0.928–1.562) | 0.163 | 409 | 1.073 (0.871–1.321) | 0.510 | 386 | 0.877 (0.716–1.073) | 0.202 | ||
| 0 | NA | NA | 136 | 1.065 (0.810–1.401 | 0.652 | 128 | 0.920 (0.700–1.208) | 0.549 | ||
| DFS | 697 | 1.000 | 245 | 1.000 | 274 | 1.000 | ||||
| 101 | 1.205 (0.935–1.554) | 0.150 | 404 | 1.039 (0.846–1.275) | 0.716 | 385 | 0.865 (0.709–1.056) | 0.153 | ||
| 0 | NA | NA | 136 | 1.052 (0.804–1.376) | 0.711 | 126 | 0.927 (0.709–1.211) | 0.580 | ||
| Relapse | 697 | 1.000 | 245 | 1.000 | 274 | 1.000 | ||||
| 101 | 0.734 (0.428–1.260) | 0.262 | 404 | 0.705 (0.484–1.028) | 0.069 | 385 | 0.761 (0.531–1.093) | 0.139 | ||
| 0 | NA | NA | 136 | 0.978 (0.614–1.557) | 0.925 | 126 | 0.622 (0.360–1.073) | 0.088 | ||
| TRM | 697 | 1.000 | 245 | 1.000 | 274 | 1.000 | ||||
| 101 | 1.388 (1.040–1.854) | 0.026 | 404 | 1.188 (0.929–1.518) | 0.169 | 385 | 0.961 (0.758–1.220) | 0.746 | ||
| 0 | NA | NA | 136 | 1.032 (0.744–1.431) | 0.851 | 126 | 1.061 (0.779–1.444) | 0.709 | ||
| aGVHD | 698 | 1.000 | 244 | 1.000 | 275 | 1.000 | ||||
| Grade II–IV | 99 | 1.018 (0.764–1.358) | 0.901 | 407 | 0.988 (0.797–1.224) | 0.912 | 283 | 0.982 (0.792–1.217) | 0.865 | |
| 0 | NA | NA | 134 | 0.812( 0.603–1.092) | 0.168 | 127 | (0.889–1.555) | 0.258 | ||
| 676 | 1.000 | 239 | 1.000 | 270 | 1.000 | |||||
| Grade III–IV | 98 | 1.286 (0.849–1.946) | 0.235 | 395 | 0.862 (0.620–1.198) | 369 | 0.809 (0.579–1.128) | 0.212 | ||
| 0 | NA | NA | 128 | 0.809 (0.512–1.278) | 123 | 1.071 (0.712–1.613) | 0.741 | |||
| 687 | 1.000 | 244 | 1.000 | 271 | 1.000 | |||||
| cGVHD | 99 | 1.089 (0.806–1.470) | 0.580 | 395 | 0.973 (0.785–1.207) | 0.805 | 378 | 1.128 (0.909–1.400) | 0.275 | |
| 0 | NA | NA | 135 | 0.791 (0.586–1.067) | 0.125 | 125 | 1.193 (0.898–1.585) | 0.223 | ||
OS, overall survival; DFS, disease free survival; TRM, treatment related mortality; aGVHD, acute graft versus host disease; cGVHD, chronic graft versus host disease; AA, major allele homozygous; Aa, heterozygous; aa, minor allele homozygous; HR, hazard ratio; CI, confidence interval; Rs number, reference single nucleotide polymorphism number; NA, not available.