Table 3.

Regression models showing the relationship between the kynurenine pathway metabolites and brain volumes within the BD (A), and HC (B) groups.

Association	Model 1 (unadjusted)	Model 2 (sex, age, and BMI)	Model 3 (sex, age, BMI, ICV)
A. BD Group	β-weight, t-score, p-value	β-weight, t-score, p-value	β-weight, t-score, p-value
KYN & Amyg	0.34, 2.7, 0.010	0.19, 1.2, 0.254	0.20, 1.4, 0.174
KynA/3HK & Hipp	0.35, 2.8, 0.008**	0.30, 2.4, 0.022*	0.25, 2.0, 0.048*
KynA/3HK & Amyg	0.32, 2.5, 0.015*	0.25, 2.0, 0.051	0.18, 1.6, 0.124
B. HC Group	β-weight, t-score, p-value	β-weight, t-score, p-value	β-weight, t-score, p-value
KYN/TRP & ICV	0.35, 2.4, 0.022	0.34, 1.7, 0.088	NA
CRP & ICV	0.44, 2.7, 0.011	0.30, 1.6, 0.131	NA
3HK & Amyg	0.15, 1.0, 0.317	0.04, 0.25, 0.805	0.03, 0.21, 0.836
KynA/3HK & Amyg	0.34, 2.4, 0.023*	0.20, 1.3, 0.185	0.21, 1.4, 0.161
CRP & Amyg	0.29, 1.7, 0.093	0.26, 1.4, 0.173	0.18, 0.9, 0.387

^*p<0.05, corrected,

^**p<0.01, corrected