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. Author manuscript; available in PMC: 2016 Jan 15.
Published in final edited form as: J Neuroimmunol. 2014 Nov 7;0:162–173. doi: 10.1016/j.jneuroim.2014.11.002

Table 1.

Regulation of inflammatory mediators two days following TBI.

Upregulated
Gene Gene Name GO Molecular Function (Mi et al., 2013) Fold
Aimp1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 - 3.4967
Ccl12 C-C motif chemokine 12 Chemokine activity 25.3867
Ccl2 C-C motif chemokine 2 Chemokine activity 21.2737
Ccl3 C-C motif chemokine 3 Chemokine activity 9.3082
Ccl4 C-C motif chemokine 4 Chemokine activity 11.4995
Ccl6 C-C motif chemokine 6 Chemokine activity 4.7027
Ccl7 C-C motif chemokine 7 Chemokine activity 7.7195
Ccl8 C-C motif chemokine 8 Chemokine activity 2.447
Ccr1 C-C chemokine receptor type 1 G-protein coupled receptor activity 2.8749
Ccr3 C-C chemokine receptor type 3 G-protein coupled receptor activity 2.4175
Ccr5 C-C chemokine receptor type 5 G-protein coupled receptor activity 2.3311
Cxcl10 C-X-C motif chemokine 10 Chemokine activity 8.96
Il10rb Interleukin 10 receptor 2 (precursor) Receptor activity 4.4568
Il11 Interleukin 11 - 5.3647
Il1b Interleukin 1 beta Cytokine receptor binding 3.1569
Il1rn Interleukin 1 receptor antagonist protein Cytokine receptor binding 2.7721
Il2rg Cytokine receptor common subunit gamma Cytokine receptor activity 2.4811
Spp1 Osteopontin Cytokine activity 38.6126
Tnf Tumor necrosis factor Tumor necrosis factor receptor binding 2.3432
Downregulated
Gene Gene Name GO Classification Fold
Ccl1 C-C motif chemokine 1 Chemokine activity 0.1293
Ccl17 Protein Ccl17 Chemokine activity 0.3987
Ccl20 C-C motif chemokine 20 Chemokine activity 0.1282
Ccl22 C-C motif chemokine 22 Chemokine activity 0.4121
Ccl24 C-C motif chemokine 24 Chemokine activity 0.1293
Ccr10 C-C chemokine receptor type 10 G-protein coupled receptor activity 0.3987
Ccr4 C-C chemokine receptor type 4 G-protein coupled receptor activity 0.132
Ccr6 C-C chemokine receptor type 6 G-protein coupled receptor activity 0.1659
Ccr8 C-C chemokine receptor type 8 G-protein coupled receptor activity 0.1247
Cd40lg CD40 ligand Tumor necrosis factor receptor binding 0.1293
Csf2 Granulocyte-macrophage colony-stimulating factor Cytokine activity 0.1345
Csf3 Granulocyte colony-stimulating factor Cytokine activity 0.2677
Cxcl1 Growth-regulated alpha protein Chemokine activity 0.3172
Cxcl11 C-X-C motif chemokine 11 Chemokine activity 0.1352
Cxcl12 Stromal cell-derived factor 1 -- 0.447
Cxcl13 C-X-C motif chemokine 13 Chemokine activity 0.1482
Cxcl15 C-X-C motif chemokine 15 Chemokine activity 0.0534
Cxcl9 C-X-C motif chemokine 9 Chemokine activity 0.1293
Cxcr3 C-X-C chemokine receptor type 3 G-protein coupled receptor activity 0.1592
Cxcr5 C-X-C chemokine receptor type 5 G-protein coupled receptor activity 0.2608
Fasl Fas ligand 0.1293
Ifng Interferon gamma Cytokine receptor binding 0.1329
Il13 Interleukin-13 Cytokine receptor binding 0.4652
Il15 Interleukin-15 Cytokine receptor binding 0.4022
Il17a Interleukin-17A Cytokine receptor binding 0.1293
Il17b Interleukin-17B -- 0.475
Il17f Interleukin-17f Cytokine receptor binding 0.251
Il21 Interleukin-21 -- 0.1535
Il27 Interleukin-27 subunit alpha -- 0.2286
Il2rb Interleukin-2 receptor subunit beta Receptor activity 0.4288
Il3 Interleukin-3 Interleukin-3 receptor binding 0.1341
Il5ra Interleukin-5 receptor subunit alpha Cytokine receptor activity 0.1912
Il7 Interleukin-7 -- 0.3085
Lta Lymphotoxin-alpha Tumor necrosis factor receptor binding 0.1809
Mif Macrophage migration inhibitory factor -- 0.458
Tnfsf10 Tumor necrosis factor ligand superfamily member 10 Tumor necrosis factor receptor binding 0.3746
Tnfsf11 Tumor necrosis factor ligand superfamily member 11 Tumor necrosis factor receptor binding 0.4371
Tnfsf13 Tumor necrosis factor ligand superfamily member 13 -- 0.3313
Tnfsf4 Tumor necrosis factor ligand superfamily member 4 Tumor necrosis factor receptor binding 0.1293
Vegfa Vascular endothelial growth factor A Growth factor activity 0.2649