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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Drug Alcohol Depend. 2014 Dec 18;0:1–19. doi: 10.1016/j.drugalcdep.2014.12.005

Figure 2.

Figure 2

Chemical structures of representative atypical DAT ligands of various types: atypical DA uptake inhibitors (top and middle rows), C1-substituted cocaine analogs (bottom left) and substrate-like partial DA releasers (bottom right). Despite their structural and mechanistic heterogeneity, atypical DAT ligands all exhibit a similar constellation of behavioral effects when compared to classical DAT inhibitors (e.g. cocaine and methylphenidate), including attenuated locomotor stimulant activity and reduced addictive liability.