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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Drug Alcohol Depend. 2014 Dec 18;0:1–19. doi: 10.1016/j.drugalcdep.2014.12.005

Figure 3.

Figure 3

Dose-dependent effects of 3α-diphenylmethoxytropane analogs on locomotor activity in mice. Ordinates, horizontal activity counts after drug administration. Abscissae, dose of drug in μmol/kg, log scale. Each point represents the average effect ± SEM determined in eight mice. The data are from the 30-min period during the first 60 min after drug administration, in which the greatest stimulant effects were obtained. Note that the fluoro-substituted compounds (A) were generally more efficacious than the other compounds, and that the bromo-substituted compounds (B) were generally the least efficacious. (Data are from Katz et al., 1999a; Hiranita et al. 2014)