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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Drug Alcohol Depend. 2014 Dec 18;0:1–19. doi: 10.1016/j.drugalcdep.2014.12.005

Figure 4.

Figure 4

Effects of presession treatment with the N-substituted BZT analogs, JHW 007 and AHN 2-005, or methylphenidate on cocaine self-administration. Each point represents the mean ±S.E.M. (n = 6–10). JHW 007, AHN 2-005, or methylphenidate were administered orally at 300, 240 or 60 min before sessions, respectively. Filled symbols represent the intravenous self- administration of cocaine after a pre-session administration of vehicle. Open symbols represent increasing doses of the pretreatments administered by gavage. Doses of JHW 007 or AHN 2-005 were 10.0 (O), 32.0 (Δ), or 100.0 (∇) mg/kg, p.o. Doses of methylphenidate were 3.2 (O), 10.0 (Δ), or 32.0 (∇)mg/kg, p.o. Abscissae: cocaine self-administration dose in milligrams per kilogram. Each point represents the mean and standard error of the mean (n=6–11). Data are from Hiranita et al. (2014).