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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Drug Alcohol Depend. 2014 Dec 18;0:1–19. doi: 10.1016/j.drugalcdep.2014.12.005

Figure 8.

Figure 8

Effects of mixed DAT/SERT releasers on extracellular dopamine (DA), extracellular serotonin (5-HT) and horizontal locomotor activity (HLA) in male rats. Rats undergoing microdialysis in the n. accumbens received sequential intravenous doses of the DAT-selective releaser PAL-353 or the non-selective DAT/SERT releaser PAL-313. Arrows indicate time of injections (1 or 3 mg/kg i.v.). Dialysate DA and 5-HT concentrations were assayed by HPLC-ECD. Data are mean ± SEM for n=6-7 rats/group.