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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Drug Alcohol Depend. 2014 Dec 18;0:1–19. doi: 10.1016/j.drugalcdep.2014.12.005

Table 1. Dopamine (DA) transporter uptake inhibition and substrate releasing effects of a series of phenethylamines as determined in rat brain synaptosomes.

Name Structure DA UI IC50 (nM) DA Release EC50 (nM) Name Structure DA UI IC50 (nM) DA Release EC50 (nM)
Phenethylamine graphic file with name nihms650639t1.jpg 39.5 ± 1.8 PAL-27 graphic file with name nihms650639t2.jpg 208 ± 13
Amphetamine graphic file with name nihms650639t3.jpg 8.7 ± 1.2 Cathinone graphic file with name nihms650639t4.jpg 83.1 ± 9
Methamphetamine graphic file with name nihms650639t5.jpg 24.5 ± 2.1 Methcathinone graphic file with name nihms650639t6.jpg 49.9 ± 3.1
PAL-99 graphic file with name nihms650639t7.jpg 88.5 ± 9.6 PAL-434 graphic file with name nihms650639t8.jpg 46.8 ± 4.0
PAL-426 graphic file with name nihms650639t9.jpg 225 ± 2.1 Mephedrone graphic file with name nihms650639t10.jpg 49.1 ± 3.1
PAL-503 graphic file with name nihms650639t11.jpg 271 ± 17 Methylone graphic file with name nihms650639t12.jpg 133.0 ± 11
PAL-505 graphic file with name nihms650639t13.jpg 2087 ± 195 PAL-429 graphic file with name nihms650639t14.jpg 411 ± 98
PAL-424 graphic file with name nihms650639t15.jpg 1013 ± 101 N-Ethylpropion graphic file with name nihms650639t16.jpg 1014 ± 80a
PAL-550 graphic file with name nihms650639t17.jpg 2596 ± 408 PAL-359 graphic file with name nihms650639t18.jpg IA
PAL-90 graphic file with name nihms650639t19.jpg IA MDPV graphic file with name nihms650639t20.jpg 4.1 ± 0.06
PAL-595 graphic file with name nihms650639t21.jpg IA Bupropion graphic file with name nihms650639t22.jpg 658 ± 178

Release EC50 and Uptake Inhibition IC50 values are reported as means ± SD and are the result of n= 3 performed in triplicate.

UI = Uptake Inhibition; IA = inactive with IC50 >10,000 nM. Cells are left blank where the major property of the compound is in the adjacent cell (releasing activity in top portion of table, or uptake inhibitory activity in the bottom portion).