Table 2. Comparison of dopamine transporter (DAT) uptake inhibition and serotonin (5-HT) releasing effects for a series of N-alkylpropiophenones (cathinones) as determined in rat brain synaptosomes.
| Name | Structure | DAT UI IC50 (nM) | 5-HT Release EC50 (nM) |
|---|---|---|---|
| N-Ethylpropion |
|
1014 ± 80a | 2118 ± 98a |
| PAL-433 |
|
533 ± 61 | 1328 ± 148 |
| PAL-586 |
|
386 ± 29 | 621 ± 141 |
| PAL-787 |
|
425 ± 22 | 356 ± 96 |
| PAL-820 |
|
592 ± 31 | 181 ± 31 |
Release EC50 and Uptake Inhibition IC50 values are reported as means ± SD and are the result of n= 3 performed in triplicate.