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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Drug Alcohol Depend. 2014 Dec 18;0:1–19. doi: 10.1016/j.drugalcdep.2014.12.005

Table 3. Dopamine (DA) uptake inhibition and releasing effects for a series of phenethylamines that display the transition from full efficacy, to partial efficacy, to uptake inhibition as determined in rat brain synaptosomes.

DAT UI DA Release
Name Structure IC50 (nM) EC50 (nM) EMAX
PAL-287 graphic file with name nihms650639t28.jpg 12.6 ± 1 102 ± 1
PAL-1046 graphic file with name nihms650639t29.jpg 10 ± 1 101 ± 3
MDMA graphic file with name nihms650639t30.jpg 108 ± 10 103 ± 2
PAL-99 graphic file with name nihms650639t31.jpg 115 ± 35 111 ± 13
PAL-169 graphic file with name nihms650639t32.jpg 296 ± 20 90 ± 1
PAL-1045 graphic file with name nihms650639t33.jpg 46 ± 11 78 ± 5
MDEA (PAL-193) graphic file with name nihms650639t34.jpg 622 ± 121 61 ± 2
PAL-218 graphic file with name nihms650639t35.jpg 1207 ± 118 66 ± 1
PAL-424 graphic file with name nihms650639t36.jpg 1013 ± 101
MDPV graphic file with name nihms650639t37.jpg 4.1 ± 0.06
PAL-233 graphic file with name nihms650639t38.jpg 9523 ± 436

Release EC50 and Uptake Inhibition IC50 values are reported as means ± SD and are the result of n= 3 performed in triplicate. Otherwise details are as for Table 1.