Table 4. Dopamine (DA) and serotonin (5-HT) releasing effects for compounds that vary in 5-HT releasing potency as determined in rat brain synaptosomes.
| Name | Structure | DA Release EC50 (nM) | 5-HT Release EC50 (nM) | DA/5-HT Ratio |
|---|---|---|---|---|
| PAL-353 |
|
24.2 ± 1.1 | 1937 ± 202 | 80 |
| PAL-303 |
|
51.5 ± 1.7 | 939 ± 76 | 18 |
| PAL-314 |
|
33.3 ± 1.3 | 218 ± 22 | 6.5 |
| PAL-313 |
|
44.1 ± 2.6 | 53.4 ± 4.1 | 1.2 |
| PAL-287 |
|
12.6 ± 0.4 | 3.4 ± 0.2 | 0.27 |
Release EC50 values are reported as means ± SD and are the result of n= 3 performed in triplicate.