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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Drug Alcohol Depend. 2014 Dec 18;0:1–19. doi: 10.1016/j.drugalcdep.2014.12.005

Table 5. Releasing potency at the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) for selected compounds.

Name Structure DAT Release EC50 (nM) VMAT2 Releasea EC50 (μM)
Amphetamine graphic file with name nihms650639t44.jpg 8.7 ± 1.2 10.5 ± 2.3
PAL-287 graphic file with name nihms650639t45.jpg 15.7 ± 1 1.25 ± 0.23
(+)-Phenmetrazine graphic file with name nihms650639t46.jpg 87.4 ± 7.8 >100
Phentermine graphic file with name nihms650639t47.jpg 262 ± 21 >100
Benzylpiperazine graphic file with name nihms650639t48.jpg 307 ± 19 >100

Release EC50 are reported as means ± SD and are the result of n= 3 performed in triplicate.

a

VMAT2 Release measured with Tyramine.