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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: J Immunol. 2014 Dec 29;194(3):1285–1291. doi: 10.4049/jimmunol.1402354

Figure 2. Wound healing is attenuated in C3−/− mice reconstituted with C3.

Figure 2

To confirm the involvement of C3 in wound healing, C3−/− mice were reconstituted with purified human C3 (middle graph). Similarly, C3−/− mice treated with sera derived from C3−/− animals (left graph) showed the same accelerated healing to that of untreated C3−/− mice, while C3−/− mice given mouse C3+/+ sera (left graph) showed slower healing similar to untreated C3+/+ mice (right graph), indicating the crucial role of C3 in the healing process. The data are expressed as percentage areas compared to the initial wounded area (100%) on the Y-axis.