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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: J Immunol. 2014 Dec 29;194(3):1285–1291. doi: 10.4049/jimmunol.1402354

Figure 4. C5−/− and C5aR1−/− mice have accelerated wound healing phenotypes similar to C3−/− mice.

Figure 4

To examine the involvement of downstream complement molecules in wound healing, we wounded A) C5−/− mice and B) C5aR1−/− mice, and compared the rate of surface area healing to that of complement-sufficient animals over time. The data are expressed as percentage areas compared to the initial wounded area (100%) on the Y-axis. We observed that both C5−/− mice and C5aR1−/− mice exhibited accelerated healing over the first days of the process, suggesting that C5a is involved in the inflammatory stage of healing.