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. Author manuscript; available in PMC: 2016 Jan 15.
Published in final edited form as: J Neuroimmunol. 2014 Nov 8;0:174–184. doi: 10.1016/j.jneuroim.2014.11.003

Figure 1.

Figure 1

Neuropathology of wild-type C57BL/6 and Jα18 knockout (KO) mice, 1 week and 2 months post infection (p.i.). Wild-type C57BL/6 and Jα18 KO mice were infected intracerebrally with the Daniels (DA) strain of Theiler’s murine encephalomyelitis virus (TMEV). (A) During the acute phase of TMEV infection, 1 week p.i., wild-type C57BL/6 and Jα18 KO mice had similar levels of meningitis (arrows), perivascular cuffing (paired arrows), and neuronal loss (arrowheads) in the hippocampus. Sections were representatives of six wild-type C57BL/6 and 10 Jα18 KO mice. Magnification, 35×. (B) During the chronic phase of TMEV infection, 2 months p.i., neither wild-type C57BL/6 nor Jα18 KO mice developed lesions in the spinal cord, while susceptible SJL/J mice developed severe demyelination (arrowheads) in the ventral funiculus of the spinal cord. Sections were representatives of 12 wild-type C57BL/6 and 21 Jα18 KO mice. Magnification, 23×. (A, B) Luxol fast blue staining.