Skip to main content
. Author manuscript; available in PMC: 2016 Jan 15.
Published in final edited form as: J Neuroimmunol. 2014 Nov 8;0:174–184. doi: 10.1016/j.jneuroim.2014.11.003

Figure 3.

Figure 3

Cytokine production in TMEV-infected wild-type C57BL/6 and Jα18 KO mice. (A) Jα18 KO (closed column) mice produced significantly lower levels of interleukin (IL)-4 compared with wild-type C57BL/6 (open column) mice 1 week p.i., while IL-4 production 1 month p.i. was around the detection limit of the enzyme-linked immunosorbent assay (ELISA) kit (dotted line). (B) The levels of IL-10 production were lower in Jα18 KO mice compared with wild-type C57BL/6 mice 1 week (*, P < 0.05) and 1 month p.i. (C) High levels of interferon (IFN)-γ production were detected in both wild-type C57BL/6 and Jα18 KO mice; there were no statistical differences between the two mouse strains. (D) No consistent trend was seen in IL-17 production between wild-type C57BL/6 and Jα18 KO mice. (A–D) MNCs were isolated from the spleen and stimulated with concanavalin A. The levels of cytokine production were assessed by ELISA. Results are mean ± SEM from 6 to 21 mice/group/time point.