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. Author manuscript; available in PMC: 2016 Jan 15.
Published in final edited form as: J Neuroimmunol. 2014 Nov 8;0:174–184. doi: 10.1016/j.jneuroim.2014.11.003

Table 2.

Contrasting roles of NKT cells in three inbred mouse strains during TMEV infection1

Experiment Mouse
strain		 MHC2 Demyelination GDVII
encephalitis		 Myocarditis Reference
Vα14 Ab3 SJL/J H2s Protective Protective No role (Tsunoda, Tanaka, 2009)
CDld KO4 BALB/c H2d Protective Protective No role (Tsunoda, Tanaka, 2008)
Jα18 K05 C57BL/6 H2b No role Detrimental Protective Current study
1

Mice were infected with the DA or GDVII strain of TMEV.

2

Haplotype of major histocompatibility complex (MHC).

3

Depletion of Vα14+ NKT cells by anti-Vα14 T cell receptor (TCR) antibody (Ab).

4

Deficiency of CD1d-restricted NKT cells.

5

Deficiency of Vα14+Jα18+ NKT cells.