Fig. 3.

A–E: lack of effect of changes in extracellular Na⁺ on intracellular pH (pH_i) and SLC4A11-C-mediated H⁺(OH⁻) flux under K⁺-valinomycin voltage-clamped conditions in the presence of 5-(N-ethyl-N-isopropyl)amiloride (EIPA). Na⁺ removal/readdition experiments were performed with 110 mM K⁺- and valinomycin-containing solutions. Na⁺ removal/readdition in the presence of Cl⁻: mock-transfected cells (A) and SLC4A11-C-expressing cells (C). Na⁺ removal/readdition in the absence of Cl⁻: mock-transfected cells (B) and SLC4A11-C expressing cells (D). Na⁺ removal/readdition in the presence of borate (10 mM): SLC4A11-C-exressing cells (E).