Table 1.

Aged-mice contractility and LV chamber dimensions by M-mode, tissue Doppler echocardiography, and gross pathology

	Ntg	TgcTnIP82S
n	15	14
Age, mo	13.8 ± 1.2	15.2 ± 2.1
HR, beats/min	677 ± 33	682 ± 34
LVEDD, mm	2.86 ± 0.03	2.88 ± 0.04
LVESD, mm	1.21 ± 0.03	1.24 ± 0.04
FS, %	57.85 ± 0.15	57.16 ± 0.16
IVCT, ms	16.73 ± 0.09	17.00 ± 0.01
ET, ms	33.00 ± 0.12	31.64 ± 0.13
IVRT, ms	24.06 ± 0.12	28.64 ± 0.18*
Tei index	1.25 ± 0.03	1.46 ± 0.04*
Ea, cm/s	0.06 ± 0.01	0.05 ± 0.01*
Aa, cm/s	0.05 ± 0.01	0.07 ± 0.01
Ea/Aa ratio	1.35 ± 0.05	0.78 ± 0.05*
Heart weight, mg	152 ± 15	147 ± 7
Heart weight/body weight ratio, mg/g	4.68 ± 2.41	4.81 ± 2.4

Values are averages ± SE; n, no. of mice.

Ntg, nontransgenic; HR, heart rate; LVEDD, left ventricle end-diastolic dimension; LVESD, left ventricle end-systolic dimension; FS, fractional shortening; IVCT, isovolumetric contraction time; ET, ejection time; IVRT, isovolumetric relaxation time; Tei index = (IVCT + IVRT)/ET; Ea, tissue Doppler imaging early diastolic myocardial velocity; Aa, tissue Doppler imaging late diastolic myocardial velocity.

^*P value ≤ 0.05.