Table 2.
Young mice (17 wk) contractility and LV chamber dimensions by M-mode and tissue Doppler echocardiography
| Ntg | TgcTnIP82S | |
|---|---|---|
| n | 8 | 9 |
| HR, beats/min | 711 ± 12 | 688 ± 5 |
| LVEDD, mm | 2.94 ± 0.05 | 2.93 ± 0.04 |
| LVESD, mm | 1.14 ± 0.03 | 1.12 ± 0.03 |
| FS, % | 61.3 ± 0.15 | 69.9 ± 0.55 |
| IVCT, ms | 16.43 ± 0.15 | 17.67 ± 0.13 |
| ET, ms | 43.71 ± 0.25 | 43.33 ± 0.2 |
| IVRT, ms | 19.29 ± 0.18 | 20.33 ± 0.15 |
| Tei index | 0.82 ± 0.04 | 0.88 ± 0.03 |
| Ea, cm/s | 0.06 ± 0.003 | 0.09 ± 0.015 |
| Aa, cm/s | 0.05 ± 0.004 | 0.06 ± 0.011 |
| Ea/Aa ratio | 1.45 ± 0.1 | 1.36 ± 0.1 |
| LV mass | 91.5 ± 3.27 | 95.99 ± 4.68 |
Values are averages ± SE; n, no. of mice.
LV mass = 1.055 × [(IVSD + LVEDD + LVPWTED)3] − (LVEDD)3, where IVSD is interventricular septal thickness at end-diastole, and LVPWTED is LV posterior wall thickness at end diastole.
*
P value ≤ 0.05.