Fig. 9.

Foxd1 is necessary for normal renin expression. A: immunostaining for renin (brown) of E17.5 kidneys show that control mice present a normal distribution of renin along developing arterioles and arteries (arrows), as well as in juxtaglomerular areas (arrowheads), whereas in Foxd1^−/− mice there is a marked reduction of renin expression (arrows). Scale bar: 100 μm. B: quantification of areas immunostained for renin per total kidney area (left) and per total vascular areas positive for α-SMA on a consecutive section (right). **P = 0.01. ***P = 0.004.