. 2014 Dec;66(Suppl 3):S1–S51. doi: 10.1016/j.ihj.2014.12.001

Table 14.

Major randomized controlled trial of statins after acute coronary syndrome.

Trial, year	n	Statin	Comparator	Duration	Mean LDL-C (mg/dl; statin v/s comparator)	% Of primary event (statin v/s comparator)
MIRACL, 2001²⁸⁵	3086	Atorvastatin 80 mg	Placebo	4months	72 v/s 135	14.8 v/s 17.4
FLORIDA, 2002²⁸⁶	540	Fluvastatin	Placebo	1 yr	104 v/s 151	33 v/s 36 (NS)
PROVE-IT TIMI 22, 2004²⁸⁷	4162	Atorvastatin 80 mg	Pravastatin 40 mg	2 yrs	62 v/s 95	22.4 v/s 26.3
A to Z, 2004²⁸⁸	4497	Simvastatin 40 mg	Placebo + simvastatin 20 mg	4 months	66 v/s 81	14.4 v/s 16.7
PACT, 2004²⁸⁹	3408	Pravastatin 20–40 mg	Placebo	1 month	Not measured	11.6 v/s 12.4 (NS)

A to Z = Aggrastat to Zocor, FLORIDA- Fluvastatin on Risk Diminishing after Myocardial Infarction, MIRACL- Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering, NS- not significant, PACT- Pravastatin in Acute Coronary Treatment, PROVE-IT TIMI 22- Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis In Myocardial Infarction 22.