Table 3.

Task-related brain response in the presence of pain.

Contrast	Region	Peak (MNI)			Cluster p	Cluster k
X	Y	Z
Task-related deactivations during pain
All participants *Adjusted threshold: p < .001, k > 25
Bilateral PCC/Cuneus/Precuneus	−10	−90	22	<.001	9787
R pINS/mINS/STG	48	−12	−4	<.001	1381
L Amygdala/aINS	−26	0	−22	<.001	384
L IFG/OFC	−28	30	−16	.01	146
L dmPFC	−10	48	40	<.001	564
R dmPFC	20	24	46	.001	279
L caudal MTG	−44	−64	24	.008	157
L S1	−22	−30	56	.05	79
R pINS	30	−24	22	.05	80
R subgenual ACC	14	42	−4	.02	112
L subgenual ACC	−4	34	−4	.03	105
mPFC	2	60	8	.01	146
L M1	−54	−4	16	.05	74
Patients > Controls p < .005, k > 25	L posterior PM/M1	−52	4	38	.01	269
Patients only *Adjusted threshold: p < .001, k > 25
R M1/pINS	56	−6	10	<.001	983
Bilateral posterior Lingual Gyrus	20	−76	−4	<.001	2923
L IFG	−46	26	6	.001	158
R PHG	20	−40	−6	<.001	215
R subgenual ACC	12	24	−10	.04	54
PCC	0	−26	34	<.001	616
R M1/S1	32	−22	52	<.001	253
L Amygdala/uncus	−24	2	−22	.05	47
Precuneus/PCC	0	−40	50	.04	49
L IFC/OFC	−30	26	−22	.05	47
R Precuneus	6	−54	34	.04	53
Controls only *Adjusted threshold: p < .001, k > 25	L Cuneus	−10	−94	30	.001	231
R Precuneus/Paracentral Lobule	16	−36	52	.02	109
L Amygdala	−28	−2	−22	.004	163
R PCC	14	−50	8	.003	171
Task-related activations during pain
Patients only *Adjusted threshold: p < .001, k > 25
R IPL/SPL	36	−44	52	<.001	354
L IPL	−30	−50	56	.007	100
R dPM	28	−2	50	.04	51
R mOG	40	−80	6	.04	52
Controls only *Adjusted threshold: p < .001, k > 25
R SPL/Precuneus/IPL	16	−68	60	<.001	1274
R Cerebellum	24	−62	−30	.05	68
R dPM/M1	42	4	32	.001	236
L Precuneus	−26	−64	28	.002	209
L SPL	−32	−56	62	<.001	723
R IOG	44	−74	−6	<.001	648
L dPM/M1	−46	6	32	.006	150
L IOG/MOG	−36	−88	10	<.001	556

p < .005, cluster-level correction p < .05.